each copy of a document conforms to the original, each original is authentic, and each signature is the genuine signature of the individual purported to have placed that signature;

if any signature under any document is an electronic signature (as opposed to a handwritten ("wet ink") signature) only, it is either a qualified electronic signature within the meaning of the eIDAS Regulation, or the method used for signing is otherwise sufficiently reliable;

the Registration Statement has been or will be declared effective by the SEC in the form reviewed by us;

at each Relevant Moment, (i) Ordinary Shares have been and shall have been, as applicable, admitted for trading on a trading system outside the European Economic Area comparable to a regulated market or a multilateral trading facility as referred to in Section 2:86c(1) DCC and (ii) no financial instruments issued by the Company (or depository receipts for or otherwise representing such financial instruments) have been or shall have been, as applicable, admitted to trading on a regulated market, multilateral trading facility or organised trading facility operating in the European Economic Area (and no request for admission of any such financial instruments to trading on any such trading venue has been or shall have been, as applicable, made);

(i) the Previous Articles were the Articles of Association in force at the Relevant Moment of issuance of Resale Shares pursuant to the June Deeds of Issue, and (ii) the Current Articles were and shall be, as applicable, the Articles of Association in force at each other Relevant Moment;

each of the Deed of Incorporation, the Deed of Conversion, the Previous Deed of Amendment and the Deed of Amendment is a valid notarial deed;

at each Relevant Moment, the authorised share capital (maatschappelijk kapitaal) of the Company allowed or shall allow, as applicable, the issuance of the Resale Shares, Registered Shares and other Registered Securities;

at each Relevant Moment, the Company had not, and shall not have, as applicable, (i) been dissolved (ontbonden), (ii) ceased to exist pursuant to a merger (fusie) or a division (splitsing), (iii) been converted (omgezet) into another legal form, either national or foreign (except pursuant to the Deed of Conversion), (iv) had its assets placed under administration (onder bewind gesteld), (v) been declared bankrupt (failliet verklaard), (vi) been granted a suspension of payments (surseance van betaling verleend), (vii) started or become subject to statutory proceedings for the restructuring of its debts (akkoordprocedure) or (viii) been made subject to similar proceedings in any jurisdiction or otherwise been limited in its power to dispose of its assets;

the Resale Shares, Registered Shares and other Registered Securities have been or shall have been, as applicable, issued and any pre-emption rights in connection therewith have been or shall have been, as applicable, excluded, pursuant to resolutions validly passed by the corporate body (orgaan) of the Company duly authorised to do so;

(i) the issue price for the Resale Shares and the Registered Shares equaled or shall equal, as applicable, at least the aggregate nominal value thereof, (ii) any pre-funded purchase price, conversion price, exchange price or exercise price, as applicable, of the Convertible Notes, Pre-Funded Warrants and Registered Securities equaled or shall equal, as applicable, at least the aggregate nominal value of the underlying Resale Shares or Registered Shares, as applicable, (iii) any such pre-funded purchase price shall be considered to have been pre-paid on the relevant Resale Shares underlying the Pre-Funded Warrants, (iv) any such issue, pre-funded purchase price, conversion price, exchange price or exercise price has been or shall have been, as applicable, satisfied in cash or by means of a set-off (verrekening) and has been or shall have been, as applicable, received and accepted by the Company ultimately upon the issuance of the relevant Resale Shares and Registered Shares, as applicable, and (v) where relevant, the Company has consented or shall have consented, as applicable, to payment in a currency other than Euro;

in respect of any payment (storting) on any Resale Shares or Registered Shares satisfied or to be satisfied, as applicable, by means of a set-off (verrekening), the Company has or shall have, as applicable, validly effected such set-off of a debt of the Company vis-à-vis the relevant subscriber for such Resale Shares or Registered Shares, as applicable, against the Company's claim on such subscriber to pay up such Resale Shares or Registered Shares, as applicable, in full in accordance with Section 6:127 DCC, the Company had or shall have, as applicable, the authority to set off such debt vis-à-vis such claim and the amount payable by the Company under such debt was or shall be, as applicable, sufficient to pay up such Resale Shares or Registered Shares, as applicable, in full by means of such set-off, in each case at the moment when the relevant Resale Shares or Registered Shares, as applicable, were or are, as applicable, issued;

any Resale Shares and Registered Shares issued or to be issued, as applicable, in connection with the conversion, exchange or exercise of Convertible Notes, Pre-Funded Warrants or other Registered Securities shall be issued pursuant to a valid conversion, exchange or exercise of such Convertible Notes, Pre-Funded Warrants or Registered Securities, as applicable, in accordance with their respective terms;

the Convertible Notes, Pre-Funded Warrants and Registered Securities (other than Registered Shares) (i) have been validly granted as rights to subscribe for Ordinary Shares (recht tot het nemen van aandelen), (ii) shall be in full force and effect upon being converted, exercised or exchanged, as applicable, and (iii) shall have been validly converted, exercised or exchanged, as applicable, in accordance with the terms thereof;

all Reviewed Documents are, have always been, and at each Relevant Moment after the date of this opinion letter shall be valid, binding and enforceable in accordance with their terms and have been duly and validly signed, executed and delivered by the respective parties thereto;

no Resale Shares, Convertible Notes, Pre-Funded Warrants, Registered Shares or other Registered Securities have been or shall be, as applicable, offered to the public (aanbieden aan het publiek) in the Netherlands other than in conformity with the Prospectus Regulation, the PRIIPs Regulation and the rules promulgated thereunder.

The Company has been duly incorporated as a besloten vennootschap met beperkte aansprakelijkheid and is validly existing as a naamloze vennootschap.

Subject to receipt by the Company of payment in full for, or other satisfaction of the issue, conversion, exchange or exercise price for, the Registered Shares, and when issued by the Company and accepted by the acquiror(s) thereof, the Registered Shares shall be validly issued, fully paid and non-assessable.

The existing Resale Shares have been validly issued and are fully paid and non-assessable.

Subject to receipt by the Company of payment in full for, or other satisfaction of the issue, conversion, exchange or exercise price for, the Resale Shares not yet existing, and when issued by the Company and accepted by the acquiror(s) thereof, those Resale Shares shall be validly issued, fully paid and non-assessable.

Opinion 1 must not be read to imply that the Company cannot be dissolved (ontbonden). A company such as the Company may be dissolved, inter alia by the competent court at the request of the company's board of directors, any interested party (belanghebbende) or the public prosecution office in certain circumstances, such as when there are certain defects in the incorporation of the company. Any such dissolution will not have retro-active effect.

Pursuant to Section 2:7 DCC, any transaction entered into by a legal entity may be nullified by the legal entity itself or its liquidator in bankruptcy proceedings (curator) if the objects of that entity were transgressed by the transaction and the other party to the transaction knew or should have known this without independent investigation (wist of zonder eigen onderzoek moest weten). The Dutch Supreme Court (Hoge Raad der Nederlanden) has ruled that in determining whether the objects of a legal entity are transgressed, not only the description of the objects in that legal entity's articles of association (statuten) is decisive, but all (relevant) circumstances must be taken into account, in particular whether the interests of the legal entity were served by the transaction. Based on the objects clause contained in the Previous Articles and the Current Articles, we have no reason to believe that, by issuing Registered Securities or the Resale Shares, the Company transgressed or would transgress, as applicable, the description of the objects contained in its Articles of Association. However, we cannot assess whether there are other relevant circumstances that must be taken into account, in particular whether the interests of the Company are served by issuing Registered Securities since this is a matter of fact.

Pursuant to Section 2:98c DCC, a company such as the Company may grant loans (leningen verstrekken) only in accordance with the restrictions set out in Section 2:98c DCC, and may not provide security (zekerheid stellen), give a price guarantee (koersgarantie geven) or otherwise bind itself, whether jointly and severally or otherwise with or for third parties (zich op andere wijze sterk maken of zich hoofdelijk of anderszins naast of voor anderen verbinden) with a view to (met het oog op) the subscription or acquisition by third parties of shares in its share capital or depository receipts. This prohibition also applies to its subsidiaries (dochtervennootschappen). It is generally assumed that a transaction entered into in violation of Section 2:98c DCC is null and void (nietig).

The opinions expressed in this opinion letter may be limited or affected by:

rules relating to Insolvency Proceedings or similar proceedings under a foreign law and other rules affecting creditors' rights generally;

the provisions of fraudulent preference and fraudulent conveyance (Actio Pauliana) and similar rights available in other jurisdictions to insolvency practitioners and insolvency office holders in bankruptcy proceedings or creditors;

claims based on tort (onrechtmatige daad);

sanctions and measures, including but not limited to those concerning export control, pursuant to European Union regulations, under the Dutch Sanctions Act 1977 (Sanctiewet 1977) or other legislation;

the Anti-Boycott Regulation, Anti Money Laundering Laws and related legislation;

any intervention, recovery or resolution measure by any regulatory or other authority or governmental body in relation to financial enterprises or their affiliated entities; and

the rules of force majeure (niet toerekenbare tekortkoming), reasonableness and fairness (redelijkheid en billijkheid), suspension (opschorting), dissolution (ontbinding), unforeseen circumstances (onvoorziene omstandigheden) and vitiated consent (i.e., duress (bedreiging), fraud (bedrog), abuse of circumstances (misbruik van omstandigheden) and error (dwaling)) or a difference of intention (wil) and declaration (verklaring).

The term "non-assessable" has no equivalent in the Dutch language and for purposes of this opinion letter such term should be interpreted to mean that a holder of an Ordinary Share shall not by reason of merely being such a holder be subject to assessment or calls by the Company or its creditors for further payment on such Ordinary Share.

This opinion letter does not purport to express any opinion or view on the operational rules and procedures of any clearing or settlement system or agency.