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P.O. Box 7113
1007 JC Amsterdam
Beethovenstraat 400
1082 PR Amsterdam
T +31 20 71 71 000
F +31 20 71 71 111
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Amsterdam, 17 October 2025.
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| 2 | ||
| a. |
drafts of documents reviewed by us will be signed in the form of those drafts, each copy of a document conforms to the original, each original is authentic, and each signature
is the genuine signature of the individual purported to have placed that signature;
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| b. |
if any signature under any document is an electronic signature (as opposed to a handwritten ("wet ink") signature) only, it is either a qualified electronic signature within
the meaning of the eIDAS Regulation, or the method used for signing is otherwise sufficiently reliable;
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| c. |
the Prospectus Supplement has been or will be declared effective by the SEC in the form reviewed by us;
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| e. |
each of the Deed of Incorporation, the Deed of Conversion and the Deed of Amendment is a valid notarial deed;
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| 3 | ||
| f. |
(i) no internal regulations (reglementen) have been adopted by any corporate body of the Company which would affect the
validity of the resolutions recorded in the Resolutions and (ii) the Current Articles are the
Articles of Association currently in force and as they will be in force at each Relevant Moment;
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| g. |
at each Relevant Moment, the Company will not have (i) been dissolved (ontbonden), (ii) ceased to exist pursuant to a merger
(fusie) or a division (splitsing), (iii) been converted (omgezet) into another legal form, either national or foreign (except pursuant to the Deed of Conversion), (iv) had its assets placed under administration (onder bewind gesteld), (v) been declared bankrupt (failliet verklaard), (vi) been granted a suspension of payments (surseance van betaling verleend), (vii) started or become subject to statutory proceedings for the restructuring of its debts (akkoordprocedure) or (viii) been made subject to similar proceedings in any jurisdiction or otherwise been limited in its power to dispose of its assets;
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| h. |
at each Relevant Moment, (i) the resolutions recorded in the Resolutions shall be in full force and effect, and (ii) the factual statements made and the confirmations given in
the Resolutions and in each Deed of Issue shall be complete and correct;
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| i. |
at each Relevant Moment, the authorised share capital (maatschappelijk kapitaal) of the Company shall allow for the issuance of the Offer Shares and the Option Shares;
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| j. |
at a Relevant Moment, the relevant Deed of Issue shall have been validly signed and executed on behalf of the Company;
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| k. |
the Offering, to the extent made in the Netherlands, has been, is and will be made in conformity with the Prospectus Regulation and the rules promulgated thereunder; and
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| l. |
the Option (i) has been validly granted as a right to subscribe for Ordinary Shares (recht tot het nemen van aandelen), (ii)
shall be in full force and effect upon being exercised and (iii) shall have been validly exercised in accordance with the terms of the Underwriting Agreement.
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| 4 | ||
| 1. |
The Company has been incorporated as a besloten vennootschap met beperkte aansprakelijkheid and is
validly existing as a naamloze vennootschap.
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| A. |
Opinion 1 must not be read to imply that the Company cannot be dissolved (ontbonden). A company such as
the Company may be dissolved, inter alia by the competent court at the request of the company's board of directors, any interested party (belanghebbende) or the public
prosecution office in certain circumstances, such as when there are certain defects in the incorporation of the company. Any such dissolution will not have retro-active effect.
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| B. |
Pursuant to Section 2:7 DCC, any transaction entered into by a legal entity may be nullified by the legal entity itself or its liquidator in bankruptcy proceedings (curator) if the objects of that entity were transgressed by the transaction and the other party to the transaction knew or should have known this without independent
investigation (wist of zonder eigen onderzoek moest weten). The Dutch Supreme Court (Hoge Raad der
Nederlanden) has ruled that in determining whether the objects of a legal entity are transgressed, not only the description of the objects in that legal entity's articles of association (statuten) is decisive, but all (relevant) circumstances must be taken into account, in particular whether the interests of the legal entity were served by the transaction. Based on the objects clause contained
in the Current Articles, we have no reason to believe that, by entering into the Reviewed Documents, the Company would transgress the description of the objects contained in its Articles of Association. However, we cannot assess whether
there are other relevant circumstances that must be taken into account, in particular whether the interests of the Company are served by entering into the Reviewed Documents since this is a matter of fact.
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| 5 | ||
| C. |
Pursuant to Section 2:98c DCC, a company such as the Company may grant loans (leningen verstrekken)
only in accordance with the restrictions set out in Section 2:98c DCC, and may not provide security (zekerheid stellen), give a price guarantee (koersgarantie geven) or otherwise bind itself, whether jointly and severally or otherwise with or for third parties (zich op andere wijze sterk maken of zich hoofdelijk of anderszins naast of voor anderen verbinden) with a view to (met het oog op) the
subscription or acquisition by third parties of shares in its share capital or depository receipts. This prohibition also applies to its subsidiaries (dochtervennootschappen).
It is generally assumed that a transaction entered into in violation of Section 2:98c DCC is null and void (nietig).
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| D. |
The opinions expressed in this opinion letter may be limited or affected by:
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| a. |
rules relating to Insolvency Proceedings or similar proceedings under a foreign law and other rules affecting creditors' rights generally;
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| b. |
the provisions of fraudulent preference and fraudulent conveyance (Actio Pauliana) and similar rights available in other
jurisdictions to insolvency practitioners and insolvency office holders in bankruptcy proceedings or creditors;
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| c. |
claims based on tort (onrechtmatige daad);
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| d. |
sanctions and measures, including but not limited to those concerning export control, pursuant to European Union regulations, under the Dutch Sanctions Act 1977 (Sanctiewet 1977) or other legislation;
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| e. |
the Anti-Boycott Regulation, Anti Money Laundering Laws and related legislation;
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| f. |
any intervention, recovery or resolution measure by any regulatory or other authority or governmental body in relation to financial enterprises or their affiliated entities;
and
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| g. |
the rules of force majeure (niet toerekenbare tekortkoming), reasonableness and fairness (redelijkheid en billijkheid), suspension (opschorting), dissolution (ontbinding), unforeseen circumstances (onvoorziene omstandigheden) and vitiated consent (i.e., duress (bedreiging), fraud (bedrog), abuse of circumstances (misbruik van omstandigheden) and error (dwaling)) or a difference of intention (wil) and declaration (verklaring).
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| 6 | ||
| F. |
This opinion letter does not purport to express any opinion or view on the operational rules and procedures of any clearing or settlement system or agency.
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| 7 | ||
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"Anti Money Laundering Laws"
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The European Anti-Money Laundering Directives, as implemented in the Netherlands in the Money
Laundering and Terrorist Financing Prevention Act (Wet ter voorkoming van witwassen en financieren van terrorisme) and the Dutch Criminal Code (Wetboek van Strafrecht).
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"Anti-Boycott Regulation"
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The Council Regulation (EC) No 2271/96 of 22 November 1996 on protecting against the effects of the extra-territorial application of legislation adopted by
a third country, and actions based thereon or resulting therefrom.
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"Articles of Association"
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The Company's articles of association (statuten) as they read from time to time.
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"Bankruptcy Code"
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The Dutch Bankruptcy Code (Faillissementswet).
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"Board"
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The Company's board of directors (bestuur).
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"Commercial Register"
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The Dutch Commercial Register (handelsregister).
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"Company"
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ATAI Life Sciences N.V., a public company with limited liability (naamloze vennootschap), registered with the Commercial Register under number 80299776.
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"Corporate Documents"
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The Deed of Incorporation, the Deed of Conversion, the Deed of Amendment, the Current Articles and the Resolutions.
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"Current Articles"
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The Articles of Association as they read
as a consequence of the execution of the Deed of Amendment.
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"DCC"
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The Dutch Civil Code (Burgerlijk Wetboek).
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"Deed of Amendment"
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The deed of amendment to the Articles of Association dated June 25, 2025.
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| 8 | ||
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"Deed of Conversion"
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The deed of conversion and amendment to the Articles of Association dated June 18, 2021.
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"Deed of Incorporation"
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The Company's deed of incorporation (akte van oprichting) dated September 10,
2020.
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"Deed of
Issue"
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The draft deed of issue of the Offer Shares or Option Shares, as the case may
be, prepared by us with references 83102964 M 58404852 and 83102964 M 58404853, respectively.
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"eIDAS Regulation"
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Regulation (EU) No 910/2014 of the European Parliament and of the Council of 23 July 2014 on electronic identification and trust services for electronic
transactions in the internal market and repealing Directive 1999/93/EC.
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"General Meeting"
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The Company's general meeting (algemene vergadering).
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"Insolvency Proceedings"
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Any insolvency proceedings within the meaning of Regulation (EU) 2015/848 of the European Parliament and of the Council of 20 May 2015 on insolvency
proceedings (recast), as amended by Regulation (EU) 2021/2260 of the European Parliament and of the Counsel of 15 December 2021, listed in Annex A thereto and any statutory proceedings for the restructuring of debts (akkoordprocedure) pursuant to the Bankruptcy Code.
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"NautaDutilh"
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NautaDutilh N.V.
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"the Netherlands"
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The European territory of the Kingdom of the Netherlands and "Dutch" is in or from
the Netherlands.
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"Offer Shares"
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23,725,000 Ordinary Shares.
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"Offering"
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The offering of Ordinary Shares as contemplated by the Prospectus Supplement.
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| 9 |
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"Option"
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The option to acquire Option Shares to be granted to the Underwriters pursuant to the Underwriting Agreement and the Resolutions.
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"Option Shares"
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Up to 3,558,750 Ordinary Shares or such
lesser number of Ordinary Shares in respect of which the Option is exercised.
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"Ordinary Shares"
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Ordinary shares in the Company's capital, with a nominal value of EUR 0.10 each.
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"Prospectus Regulation"
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Regulation (EU) 2017/1129 of the European Parliament and of the Council of 14 June 2017 on the prospectus to be published when securities are offered to
the public or admitted to trading on a regulated market, and repealing Directive 2003/71/EC.
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"Prospectus Supplement"
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The Company's prospectus supplement to the Registration Statement with respect to the Registered Shares, dated October 16, 2025, filed with the
SEC in the form reviewed by us on or about the date of this opinion letter.
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"Registration Statement"
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The Company's shelf registration statement on Form S-3, as declared effective by
the SEC on September 29, 2025.
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"Relevant Moment"
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Each time when Offer Shares or Option Shares are issued pursuant to the execution of a Deed of Issue.
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"Resolutions"
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Each of the following:
a. the written resolutions of
the Board, dated October 15, 2025; and
b. the resolutions described in the definitive proxy statement for the General Meeting held on 15 May 2025, filed with the SEC on 21 April 2025 and the voting results relating to such resolutions described in the Company's Current
Report on Form 8-K filed with the SEC on 21 May 2025; and
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| 10 |
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c. the minutes of a meeting of
the pricing committee established by the Board held on October 16, 2025.
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"Reviewed Documents"
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Each Deed of Issue and the Underwriting Agreement.
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"SEC"
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The United States Securities and Exchange Commission.
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"Underwriters"
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The Underwriters, as defined in the Underwriting Agreement.
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"Underwriting Agreement"
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The signed underwriting agreement entered into between the Company and the Underwriters dated October 16, 2025.
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