Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (No. 333-280640) of Alumis Inc. of our report dated March 19, 2025 relating to the financial statements, which appears in this Form 10-K.

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/s/ PricewaterhouseCoopers LLP

San Jose, California

March 19, 2025