Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

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We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (Nos. 333-293090, 333-287922, 333-285925, and 333-280640) and Form S-3 (No. 333-288510) of Alumis Inc. of our report dated March 19, 2026 relating to the financial statements, which appears in this Form 10-K.

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/s/ PricewaterhouseCoopers LLP

San Jose, California

March 19, 2026