Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption "Experts" in the Registration Statement (Form S-4) and related Prospectuses of ProKidney Corp. for the
registration of Class A and B common stock and to the incorporation by reference therein of our report dated March 17 , 2025, with respect to the consolidated financial statements of ProKidney Corp. included in its Annual Report (Form 10-K) for the
year ended December 31, 2024, filed with the Securities and Exchange Commission.
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/s/ Ernst & Young
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Atlanta, Georgia
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March 31, 2025
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