Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption "Experts" in the Registration Statement (Form S-4) and related Prospectuses of ProKidney Corp. for the
registration of Class A and B common stock and to the incorporation by reference therein of our report dated March 17, 2025, with respect to the consolidated financial statements of ProKidney Corp. included in its Annual Report (Form 10-K) for the
year ended December 31, 2024, filed with the Securities and Exchange Commission.
/s/ Ernst & Young
Atlanta, Georgia
July 3, 2025