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        <entityName>Senti Biosciences Holdings, Inc.</entityName>
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            <street1>2 Corporate Drive, First Floor</street1>
            <city>South San Francisco</city>
            <stateOrCountry>CA</stateOrCountry>
            <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
            <zipCode>94080</zipCode>
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            <entityName>Senti Holdings, Inc.</entityName>
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                <city>South San Francisco</city>
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                <zipCode>94080</zipCode>
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            <entityName>Senti Biosciences, Inc.</entityName>
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                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94080</zipCode>
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            <relatedPersonName>
                <firstName>Timothy</firstName>
                <lastName>Lu</lastName>
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            <relatedPersonAddress>
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                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94080</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
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            <relationshipClarification>Chief Executive Officer of each Issuer and Director of Senti Biosciences Holdings, Inc.</relationshipClarification>
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        <relatedPersonInfo>
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                <firstName>Edward</firstName>
                <lastName>Mathers</lastName>
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                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94080</zipCode>
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            <relationshipClarification>Director of Senti Biosciences Holdings, Inc.</relationshipClarification>
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        <relatedPersonInfo>
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                <firstName>Frances</firstName>
                <middleName>D.</middleName>
                <lastName>Schulz</lastName>
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                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94080</zipCode>
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        <relatedPersonInfo>
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                <firstName>Donald</firstName>
                <lastName>Tang</lastName>
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            <relatedPersonAddress>
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                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94080</zipCode>
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        <relatedPersonInfo>
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                <firstName>Brenda</firstName>
                <lastName>Cooperstone</lastName>
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                <city>South San Francisco</city>
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        <relatedPersonInfo>
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                <firstName>James</firstName>
                <middleName>J.</middleName>
                <lastName>Collins</lastName>
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                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94080</zipCode>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Feng</firstName>
                <lastName>Hsiung</lastName>
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        <relatedPersonInfo>
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                <lastName>Baum</lastName>
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                <zipCode>94080</zipCode>
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        <relatedPersonInfo>
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                <firstName>Jay</firstName>
                <lastName>Cross</lastName>
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                <zipCode>94080</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kanya</firstName>
                <lastName>Rajangam</lastName>
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            <relatedPersonRelationshipList>
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            <relationshipClarification>President, Head of Research and Development and Chief Medical Officer of Senti Biosciences Holdings, Inc.</relationshipClarification>
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    <offeringData>
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            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-05-20</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
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        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Guarantee</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
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            <clarificationOfResponse></clarificationOfResponse>
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        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>40000000</totalOfferingAmount>
            <totalAmountSold>10000000</totalAmountSold>
            <totalRemaining>30000000</totalRemaining>
            <clarificationOfResponse>Senti Holdings, Inc. sold notes convertible into its Common Stock or exchangeable into shares of Senti Biosciences Holdings, Inc. Common Stock and guaranteed by Senti Biosciences Holdings, Inc. and certain of its subsidiaries.</clarificationOfResponse>
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        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
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                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
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        <signatureBlock>
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            <signature>
                <issuerName>Senti Biosciences Holdings, Inc.</issuerName>
                <signatureName>/s/ Timothy Lu</signatureName>
                <nameOfSigner>Timothy Lu</nameOfSigner>
                <signatureTitle>Chief Executive Officer</signatureTitle>
                <signatureDate>2026-06-03</signatureDate>
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            <signature>
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            <signature>
                <issuerName>Senti Biosciences, Inc.</issuerName>
                <signatureName>/s/ Timothy Lu</signatureName>
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                <signatureTitle>Chief Executive Officer</signatureTitle>
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