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Profusa, Inc.

626 Bancroft Way
Suite A
Berkeley, CA 94710

 

August 21, 2025

 

VIA EDGAR

 

U.S. Securities and Exchange Commission

Division of Corporate Finance

Washington, DC 20549

 

Re:Profusa, Inc.
  

Registration Statement on Form S-1

File No. 333-289461

 

Ladies and Gentlemen:

 

Pursuant to Rule 461 of the Securities Act of 1933, as amended, Profusa, Inc., a Delaware corporation (the “Company”), hereby respectfully requests that the effective date for the Registration Statement referred to above be accelerated so that it will be declared effective at 4:30 P.M. (Eastern Time) on August 25, 2025, or as soon thereafter as possible on such date.

 

  Very truly yours,
   
  Profusa, Inc.
     
  By: /s/ Ben C. Hwang
    Name: Ben C. Hwang
    Title: Chief Executive Officer