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SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Name of Issuer)

(Title of Class of Securities)

(CUSIP Number)

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13D/A 0001193125-24-244214 0001913257 XXXXXXXX LIVE 1 Common Stock, $0.0001 par value 11/21/2025 false 0001878313 552641102 MAIA Biotechnology, Inc. 444 WEST LAKE STREET, Suite 1700 CHICAGO IL 60606 Vlad Vitoc (312) 416-8592 444 WEST LAKE STREET, Suite 1700 CHICAGO IL 60606 Richard A. Friedman, Esq. (212) 653-8700 30 Rockefeller Plaza New York NY 10112 Greg Carney, Esq. (212) 653-8700 30 Rockefeller Plaza New York NY 10112 Sheppard Mullin (212) 653-8700 30 Rockefeller Plaza New York NY 10112 0001913257 N Vlad Vitoc PF N X1 3285623.00 560729.00 3285623.00 560729.00 3846352.00 N 9.66 IN (1) Consists of 3,846,352 shares consisting of: (i) 903,421 shares of common stock directly held by Mr. Vitoc and 210,100 shares of common stock directly held by his spouse, and (ii) 2,382,202 shares of common stock issuable upon the exercise of stock options and warrants directly held by Mr. Vitoc, 28,159 shares of common stock issuable upon the exercise of stock options directly held by Mr. Vitoc's spouse, 161,235 shares of common stock issuable upon the exercise of stock options directly held by Maia Laetitia Cristian Vitoc 2022 MAIA Irrevocable Trust, for the benefit of Mr. Vitoc's child, for which Mr. Vitoc's spouse serves as trustee, and 161,235 shares of common stock issuable upon the exercise of stock options directly held by Leia Violeta Ioana Vitoc 2022 MAIA Irrevocable Trust, for the benefit of Mr. Vitoc's child, for which Mr. Vitoc's spouse serves as trustee. Mr. Vitoc disclaims beneficial ownership of the shares beneficially owned by his spouse, Maia Laetitia Cristian Vitoc 2022 MAIA Irrevocable Trust, and Leia Violeta Ioana Vitoc 2022 MAIA Irrevocable Trust. (2) Based on 39,805,300 shares of Common Stock outstanding as of December 2, 2025, calculated by adding (i) the 37,072,469 shares of Common Stock outstanding as of December 2, 2025 according to the Company's records, and (ii) the 2,732,831 shares of Common Stock beneficially owned by the Reporting Person, which are issuable upon the conversion of options and warrants exercisable within 60 days of the date hereof. Common Stock, $0.0001 par value MAIA Biotechnology, Inc. 444 WEST LAKE STREET, Suite 1700 CHICAGO IL 60606 This Statement of Beneficial Ownership on Schedule 13D is filed by the Reporting Person (as defined below) on December 2, 2025, (this "Statement" or "Schedule 13D") and relates to the common stock, $0.0001 par value per share (the "Common Stock") of MAIA Biotechnology, Inc., a Delaware corporation (the "Company"). The Company's principal executive offices are located at 444 West Lake Street, Suite 1700, Chicago, IL 60606. This Statement is filed by Vlad Vitoc. Mr. Vitoc is the Chief Executive Officer and Chairman of the Board of Directors of the Company. The principal business address of Mr. Vitoc is 444 West Lake Street, Suite 1700, Chicago, IL 60606. Mr. Vitoc is a citizen of the United States. The foregoing person is sometimes referred to herein as the "Reporting Person". The Reporting Person has not during the last five years been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors). The Reporting Person has not during the last five years been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws. The information contained in rows 7, 8, 9, 10, 11 and 13 on the cover page of this Schedule 13D is incorporated by reference in its entirety into this Item 3. The shares of Common Stock that the Reporting Person beneficially owns were acquired through grants of equity awards pursuant to the Issuer's various equity incentive plans or through open market purchases at various times with personal funds of the Reporting Person. The Reporting Person acquired the Common Stock reported in this Statement for investment purposes. The Reporting Person may in the future acquire additional Common Stock or dispose of some or all of the Common Stock held by the Reporting Person in open-market transactions or privately negotiated transactions, on such terms and at such times as the Reporting Person may deem advisable. The Reporting Person may engage in short selling or hedging or similar transactions with respect to the Common Stock, on such terms and at such times as the Reporting Person may deem advisable, subject to applicable law. The Reporting Person has no present plan or proposal that would result in any of the actions described in paragraphs (a) through (j) of Item 4 of Schedule 13D. The Reporting Person reserves the right in the future to formulate any such plans or proposals, and to take any actions with respect to their investments in the Company, including any or all of the actions described in paragraphs (a) through (j) of Item 4 of Schedule 13D. See responses to Items 11 and 13 on the cover page. See responses to Items 7, 8, 9 and 10 on the cover page. The Reporting Person purchased 94,300 shares of Common Stock in the following transactions during the past 60 days. All shares of Common Stock reported below were purchased by the Reporting Person in the open market. Date Number of Shares Purchased Average Purchase Price 11/21/2025 1,800 $0.92 11/24/2025 10,000 $0.9891 11/25/2025 10,500 $0.9661 11/26/2025 22,000 $1.0463 11/28/2025 50,000 $1.1366 Not applicable. Not applicable. Except as described under Items 3, 4 and 5 and as set out in Item 6, to the best knowledge of the Reporting Person, there are no contracts, arrangements, understandings or relationships (legal or otherwise) between these shareholders and any other person with respect to any securities of the Company, including but not limited to transfer or voting of any securities of the Company, finder's fees, joint ventures, loan or option arrangements, puts or calls, guarantees of profits, division of profits or loss, or the giving or withholding of proxies, or a pledge or contingency the occurrence of which would give another person voting power over the securities of the Company. Vlad Vitoc /s/ Vlad Vitoc Vlad Vitoc 12/04/2025