December 17, 2024

Keith Gottesdiener
Chief Executive Officer
Prime Medicine, Inc.
60 First Street
Cambridge, MA 02141

       Re: Prime Medicine, Inc.
           Registration Statement on Form S-3
           Filed December 13, 2024
           File No. 333-283780
Dear Keith Gottesdiener:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Tamika Sheppard at 202-551-8346 with any questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Life
Sciences