Document

We consent to the use of our report dated March 5, 2025 on the consolidated financial statements of Zymeworks Inc. (the “Entity”), which comprise the consolidated balance sheets as of December 31, 2024 and 2023, the consolidated statements of (loss) income and comprehensive (loss) income, changes in stockholders’ equity, and cash flows for each of the years in the three-year period ended December 31, 2024, and the related notes (collectively the “consolidated financial statements”), which is included in the Annual Report on Form 10-K of the Entity for the fiscal year ended December 31, 2024.

We also consent to the incorporation by reference of such report in the Registration Statements (Nos. 333-277721, 333-270338, 333-225556-01, 333-257819-01, 333-263043-01 and 333-263042-01) on Form S-8, and (Nos. 333-279073 and 333-277751) on Form S-3 of the Entity.