<?xml version="1.0" ?><inf:proxyVoteTable xmlns:inf="http://www.sec.gov/edgar/document/npxproxy/informationtable"><inf:proxyTable><inf:issuerName>Ovid Therapeutics Inc.</inf:issuerName><inf:cusip>690469101</inf:cusip><inf:isin>US6904691010</inf:isin><inf:meetingDate>07/09/2025</inf:meetingDate><inf:voteDescription>Advisory approval of the compensation paid to our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>84121.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>84121.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Greenlight Capital Re, Ltd.</inf:issuerName><inf:cusip>G4095J109</inf:cusip><inf:isin>KYG4095J1094</inf:isin><inf:meetingDate>07/29/2025</inf:meetingDate><inf:voteDescription>To consider and cast a non-binding advisory vote on a resolution approving the compensation of the Company's named executive officers as disclosed pursuant to the compensation disclosure rules of the Securities and Exchange Commission.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4385.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>4385.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Wave Life Sciences Ltd.</inf:issuerName><inf:cusip>Y95308105</inf:cusip><inf:isin>SG9999014716</inf:isin><inf:meetingDate>08/05/2025</inf:meetingDate><inf:voteDescription>To approve, by a non-binding advisory vote, the compensation of our named executive officers as disclosed in the proxy statement</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>114814.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>114814.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Wave Life Sciences Ltd.</inf:issuerName><inf:cusip>Y95308105</inf:cusip><inf:isin>SG9999014716</inf:isin><inf:meetingDate>08/05/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis only, the frequency of holding future shareholder advisory votes on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>114814.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>114814.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Immunovant, Inc.</inf:issuerName><inf:cusip>45258J102</inf:cusip><inf:isin>US45258J1025</inf:isin><inf:meetingDate>08/27/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>337473.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>337473.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Doximity, Inc.</inf:issuerName><inf:cusip>26622P107</inf:cusip><inf:isin>US26622P1075</inf:isin><inf:meetingDate>08/28/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation paid to the Company's named executive officers for the fiscal year ended March 31, 2025.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>100.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>100.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Replimune Group, Inc.</inf:issuerName><inf:cusip>76029N106</inf:cusip><inf:isin>US76029N1063</inf:isin><inf:meetingDate>09/03/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of Replimune Group, Inc.'s named executive officers for the fiscal year ended March 31, 2025.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2131.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2131.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Vistagen Therapeutics, Inc.</inf:issuerName><inf:cusip>92840H400</inf:cusip><inf:isin>US92840H4002</inf:isin><inf:meetingDate>09/09/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation paid to the Company's named executive officers (NEOS).</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>390477.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>390477.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Roivant Sciences Ltd.</inf:issuerName><inf:cusip>G76279101</inf:cusip><inf:isin>BMG762791017</inf:isin><inf:meetingDate>09/10/2025</inf:meetingDate><inf:voteDescription>To cast a non-binding, advisory vote to approve the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1428820.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>1428820.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Grace Therapeutics, Inc.</inf:issuerName><inf:cusip>00439U104</inf:cusip><inf:isin>US00439U1043</inf:isin><inf:meetingDate>09/12/2025</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>164669.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>164669.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Verona Pharma Plc</inf:issuerName><inf:cusip>925050106</inf:cusip><inf:isin>US9250501064</inf:isin><inf:meetingDate>09/24/2025</inf:meetingDate><inf:voteDescription>To approve, on an advisory, non-binding basis, the compensation that may be paid or become payable to the Company's named executive officers in connection with the Transaction, as disclosed in the table entitled "Potential Payments to Named Executive Officers" beginning on page 70 of the proxy statement, including the associated narrative discussion, and the agreements or understandings pursuant to which such compensation may be paid or become payable.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>33790.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>33790.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Howard Hughes Holdings Inc.</inf:issuerName><inf:cusip>44267T102</inf:cusip><inf:isin>US44267T1025</inf:isin><inf:meetingDate>09/30/2025</inf:meetingDate><inf:voteDescription>Advisory vote to approve executive officer compensation</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>534.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>534.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>KalVista Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>483497103</inf:cusip><inf:isin>US4834971032</inf:isin><inf:meetingDate>10/01/2025</inf:meetingDate><inf:voteDescription>Approval, on a non-binding advisory basis, of the compensation paid by us to our named executive officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>10000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>10000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Dayforce, Inc.</inf:issuerName><inf:cusip>15677J108</inf:cusip><inf:isin>US15677J1088</inf:isin><inf:meetingDate>11/12/2025</inf:meetingDate><inf:voteDescription>A proposal to approve, on an advisory (non-binding) basis, the compensation that may be paid or become payable to Dayforce's named executive officers in connection with the transactions contemplated by the merger agreement, including consummation of the merger.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>7750.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>7750.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Rezolute, Inc.</inf:issuerName><inf:cusip>76200L309</inf:cusip><inf:isin>US76200L3096</inf:isin><inf:meetingDate>11/19/2025</inf:meetingDate><inf:voteDescription>To approve, by a non-binding advisory vote, the compensation of the Company's named executive officers as disclosed in the Executive Compensation section of the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>771869.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>771869.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>iBio, Inc.</inf:issuerName><inf:cusip>451033708</inf:cusip><inf:isin>US4510337086</inf:isin><inf:meetingDate>11/20/2025</inf:meetingDate><inf:voteDescription>To approve, on an advisory, non-binding basis, the compensation of our named executive officers ("say-on-pay").</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>27000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>27000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>iBio, Inc.</inf:issuerName><inf:cusip>451033708</inf:cusip><inf:isin>US4510337086</inf:isin><inf:meetingDate>11/20/2025</inf:meetingDate><inf:voteDescription>To approve, on an advisory, non-binding basis, the frequency of future executive compensation advisory votes.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>27000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>27000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Akero Therapeutics, Inc.</inf:issuerName><inf:cusip>00973Y108</inf:cusip><inf:isin>US00973Y1082</inf:isin><inf:meetingDate>12/02/2025</inf:meetingDate><inf:voteDescription>To approve, on an advisory, non-binding basis, the payment of certain compensation that may be paid or become payable by Akero to its named executive officers in connection with the Merger.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>69001.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>69001.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Merus N.V.</inf:issuerName><inf:cusip>N5749R100</inf:cusip><inf:isin>NL0011606264</inf:isin><inf:meetingDate>12/09/2025</inf:meetingDate><inf:voteDescription>Non-binding advisory proposal to approve certain compensation arrangements</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>68863.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>68863.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Neuphoria Therapeutics Inc.</inf:issuerName><inf:cusip>64136E102</inf:cusip><inf:isin>US64136E1029</inf:isin><inf:meetingDate>12/12/2025</inf:meetingDate><inf:voteDescription>To approve (on a non-binding advisory basis) the compensation of our named executive officers as described in the accompanying materials.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2675.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2675.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Neuphoria Therapeutics Inc.</inf:issuerName><inf:cusip>64136E102</inf:cusip><inf:isin>US64136E1029</inf:isin><inf:meetingDate>12/12/2025</inf:meetingDate><inf:voteDescription>To approve (on a non-binding advisory basis) the frequency of holding an advisory vote on the compensation of our named executive officers in future years.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2675.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>2675.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Neuphoria Therapeutics Inc.</inf:issuerName><inf:cusip>64136E102</inf:cusip><inf:isin>US64136E1029</inf:isin><inf:meetingDate>12/12/2025</inf:meetingDate><inf:voteDescription>The Company's proposal to approve, on a non-binding advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>0.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan></inf:proxyTable><inf:proxyTable><inf:issuerName>Neuphoria Therapeutics Inc.</inf:issuerName><inf:cusip>64136E102</inf:cusip><inf:isin>US64136E1029</inf:isin><inf:meetingDate>12/12/2025</inf:meetingDate><inf:voteDescription>The Company's proposal to approve, on a non-binding advisory basis, the frequency of an advisory vote on the compensation of the Company's named executive officers in future years.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>0.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan></inf:proxyTable><inf:proxyTable><inf:issuerName>TherapeuticsMD, Inc.</inf:issuerName><inf:cusip>88338N206</inf:cusip><inf:isin>US88338N2062</inf:isin><inf:meetingDate>12/15/2025</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers for the fiscal year ended December 31, 2024;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>209210.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>209210.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>TherapeuticsMD, Inc.</inf:issuerName><inf:cusip>88338N206</inf:cusip><inf:isin>US88338N2062</inf:isin><inf:meetingDate>12/15/2025</inf:meetingDate><inf:voteDescription>To provide a non-binding advisory vote on the frequency of future non-binding advisory votes on the compensation of our named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>209210.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>209210.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Electronic Arts Inc.</inf:issuerName><inf:cusip>285512109</inf:cusip><inf:isin>US2855121099</inf:isin><inf:meetingDate>12/22/2025</inf:meetingDate><inf:voteDescription>To consider and vote on a proposal to approve, on an advisory (non-binding) basis, the compensation that may be paid or become payable to the Company's named executive officers in connection with the transactions contemplated by the merger agreement, including consummation of the merger.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4936.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>4936.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Astria Therapeutics, Inc.</inf:issuerName><inf:cusip>04635X102</inf:cusip><inf:isin>US04635X1028</inf:isin><inf:meetingDate>01/21/2026</inf:meetingDate><inf:voteDescription>To cast a vote, on a non-binding, advisory basis, to approve the Merger-related named executive officer compensation as disclosed in the table entitled "Golden Parachute Compensation" and its accompanying footnotes which is included in the section of the proxy statement entitled "The Merger-Interests of Astria's Directors and Executive Officers in the Merger," as required by Section 14A of the Securities Exchange Act of 1934, as amended, which was enacted as part of the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>127037.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>127037.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Plymouth Industrial REIT, Inc.</inf:issuerName><inf:cusip>729640102</inf:cusip><inf:isin>US7296401026</inf:isin><inf:meetingDate>01/22/2026</inf:meetingDate><inf:voteDescription>To approve, by a non-binding, advisory vote, the compensation that may be paid or become payable to the Company's named executive officers in connection with the transactions contemplated by the Merger Agreement; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>41065.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>41065.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Kenvue Inc.</inf:issuerName><inf:cusip>49177J102</inf:cusip><inf:isin>US49177J1025</inf:isin><inf:meetingDate>01/29/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation that may be paid or become payable to Kenvue Inc.'s named executive officers that is based on or otherwise relates to the transactions contemplated by the Merger Agreement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2229.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2229.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>KALA BIO, Inc.</inf:issuerName><inf:cusip>483119301</inf:cusip><inf:isin>US4831193010</inf:isin><inf:meetingDate>01/30/2026</inf:meetingDate><inf:voteDescription>Approval of a non-binding advisory vote on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>141480.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>141480.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Brighthouse Financial, Inc.</inf:issuerName><inf:cusip>10922N103</inf:cusip><inf:isin>US10922N1037</inf:isin><inf:meetingDate>02/12/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory (non-binding) basis, the compensation that may be paid or become payable to Brighthouse Financial, Inc.'s named executive officers that is based on or otherwise relates to the Merger; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>77363.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>77363.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Lite Strategy, Inc.</inf:issuerName><inf:cusip>55279B301</inf:cusip><inf:isin>US55279B3015</inf:isin><inf:meetingDate>02/12/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>488531.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>488531.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Ventyx Biosciences, Inc.</inf:issuerName><inf:cusip>92332V107</inf:cusip><inf:isin>US92332V1070</inf:isin><inf:meetingDate>03/03/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation that will or may become payable by Ventyx Biosciences, Inc. to its named executive officers in connection with the merger of merger sub with and into Ventyx Biosciences, Inc.; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1508118.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1508118.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Pfizer Inc.</inf:issuerName><inf:cusip>717081103</inf:cusip><inf:isin>US7170811035</inf:isin><inf:meetingDate>04/23/2026</inf:meetingDate><inf:voteDescription>2026 advisory approval of executive compensation</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>62400.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>62400.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Biohaven Ltd.</inf:issuerName><inf:cusip>G1110E107</inf:cusip><inf:isin>VGG1110E1079</inf:isin><inf:meetingDate>04/28/2026</inf:meetingDate><inf:voteDescription>A non-binding advisory vote on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>30875.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>30875.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Sanofi</inf:issuerName><inf:cusip>80105N105</inf:cusip><inf:isin>US80105N1054</inf:isin><inf:meetingDate>04/29/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Frederic Oudea, Chairman of the Board</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>429019.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>429019.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Sanofi</inf:issuerName><inf:cusip>80105N105</inf:cusip><inf:isin>US80105N1054</inf:isin><inf:meetingDate>04/29/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Paul Hudson, CEO</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>429019.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>429019.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Boston Scientific Corporation</inf:issuerName><inf:cusip>101137107</inf:cusip><inf:isin>US1011371077</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>10000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>10000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Gilead Sciences, Inc.</inf:issuerName><inf:cusip>375558103</inf:cusip><inf:isin>US3755581036</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our Named Executive Officers as presented in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>629.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>629.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Healthpeak Properties, Inc.</inf:issuerName><inf:cusip>42250P103</inf:cusip><inf:isin>US42250P1030</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>Approval of 2025 executive compensation on an advisory basis.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>600.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>600.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inspire Medical Systems, Inc.</inf:issuerName><inf:cusip>457730109</inf:cusip><inf:isin>US4577301090</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory (non-binding) basis, of the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>156546.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>156546.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inspire Medical Systems, Inc.</inf:issuerName><inf:cusip>457730109</inf:cusip><inf:isin>US4577301090</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>Approval, on a advisory (non-binding) basis, of the frequency of future advisory votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>156546.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>156546.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Intuitive Surgical, Inc.</inf:issuerName><inf:cusip>46120E602</inf:cusip><inf:isin>US46120E6023</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>To approve, by advisory vote, the compensation of the Company's Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1830.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1830.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Lexicon Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>528872302</inf:cusip><inf:isin>US5288723027</inf:isin><inf:meetingDate>04/30/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve the compensation paid to the Company's named executive officers</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>644587.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>644587.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Masimo Corporation</inf:issuerName><inf:cusip>574795100</inf:cusip><inf:isin>US5747951003</inf:isin><inf:meetingDate>05/01/2026</inf:meetingDate><inf:voteDescription>To consider and vote on the proposal to approve, on a non-binding, advisory basis, the compensation that may be paid or become payable to Masimo's named executive officers that is based on or otherwise relates to the Merger (the "Compensation Proposal").</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>15000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>15000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Eli Lilly and Company</inf:issuerName><inf:cusip>532457108</inf:cusip><inf:isin>US5324571083</inf:isin><inf:meetingDate>05/04/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation paid to the company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>35.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>35.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Danaher Corporation</inf:issuerName><inf:cusip>235851102</inf:cusip><inf:isin>US2358511028</inf:isin><inf:meetingDate>05/05/2026</inf:meetingDate><inf:voteDescription>To approve on an advisory basis the Company's named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>26761.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>26761.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Avantor, Inc.</inf:issuerName><inf:cusip>05352A100</inf:cusip><inf:isin>US05352A1007</inf:isin><inf:meetingDate>05/07/2026</inf:meetingDate><inf:voteDescription>Advisory Approval of Named Executive Officer Compensation</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>80000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>80000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Avantor, Inc.</inf:issuerName><inf:cusip>05352A100</inf:cusip><inf:isin>US05352A1007</inf:isin><inf:meetingDate>05/07/2026</inf:meetingDate><inf:voteDescription>Advisory Vote on the Frequency of Future Advisory Votes on Executive Compensation</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>80000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>80000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Abivax SA</inf:issuerName><inf:cusip>00370M103</inf:cusip><inf:isin>US00370M1036</inf:isin><inf:meetingDate>05/11/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Sylvie Gregoire, Chairwoman of the Board</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1311529.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>1311529.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Abivax SA</inf:issuerName><inf:cusip>00370M103</inf:cusip><inf:isin>US00370M1036</inf:isin><inf:meetingDate>05/11/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Marc de Garidel, CEO</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1311529.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>1311529.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Core Scientific, Inc.</inf:issuerName><inf:cusip>21874A106</inf:cusip><inf:isin>US21874A1060</inf:isin><inf:meetingDate>05/12/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3961.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>3961.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Alexandria Real Estate Equities, Inc.</inf:issuerName><inf:cusip>015271109</inf:cusip><inf:isin>US0152711091</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>To cast a non-binding, advisory vote on a resolution to approve the compensation of the Company's named executive officers, as more particularly described in the accompanying Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>19500.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>19500.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Corbus Pharmaceuticals Holdings, Inc.</inf:issuerName><inf:cusip>21833P301</inf:cusip><inf:isin>US21833P3010</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the executive compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>147623.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>147623.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Corbus Pharmaceuticals Holdings, Inc.</inf:issuerName><inf:cusip>21833P301</inf:cusip><inf:isin>US21833P3010</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>To vote, on an advisory basis, on how often the Company will conduct an advisory vote on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>147623.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>147623.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Delcath Systems, Inc.</inf:issuerName><inf:cusip>24661P807</inf:cusip><inf:isin>US24661P8077</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers as disclosed in the accompanying proxy statement ("Proxy Statement").</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>224385.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>224385.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Indivior Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>45579U109</inf:cusip><inf:isin>US45579U1097</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>70.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>70.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Indivior Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>45579U109</inf:cusip><inf:isin>US45579U1097</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>To indicate, on an advisory basis, the preferred frequency of shareholder advisory votes on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>70.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>70.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Insmed Incorporated</inf:issuerName><inf:cusip>457669307</inf:cusip><inf:isin>US4576693075</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>An advisory vote on the 2025 compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3582.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>3582.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Vertex Pharmaceuticals Incorporated</inf:issuerName><inf:cusip>92532F100</inf:cusip><inf:isin>US92532F1003</inf:isin><inf:meetingDate>05/13/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>9812.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>9812.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Prothena Corporation plc</inf:issuerName><inf:cusip>G72800108</inf:cusip><inf:isin>IE00B91XRN20</inf:isin><inf:meetingDate>05/14/2026</inf:meetingDate><inf:voteDescription>To approve, in a non-binding advisory vote, the compensation of the executive officers named in the Company's Proxy Statement for the Annual General Meeting.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>753455.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>753455.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Ultragenyx Pharmaceutical Inc.</inf:issuerName><inf:cusip>90400D108</inf:cusip><inf:isin>US90400D1081</inf:isin><inf:meetingDate>05/14/2026</inf:meetingDate><inf:voteDescription>Advisory (non-binding) vote to approve the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>13400.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>13400.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Krystal Biotech, Inc.</inf:issuerName><inf:cusip>501147102</inf:cusip><inf:isin>US5011471027</inf:isin><inf:meetingDate>05/15/2026</inf:meetingDate><inf:voteDescription>Approval of the compensation of the Company's named executive officers, on a non-binding, advisory basis.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>18523.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>18523.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Nurix Therapeutics, Inc.</inf:issuerName><inf:cusip>67080M103</inf:cusip><inf:isin>US67080M1036</inf:isin><inf:meetingDate>05/15/2026</inf:meetingDate><inf:voteDescription>To approve, a non-binding advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>48010.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>48010.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Teleflex Incorporated</inf:issuerName><inf:cusip>879369106</inf:cusip><inf:isin>US8793691069</inf:isin><inf:meetingDate>05/15/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>18287.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>18287.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Larimar Therapeutics, Inc.</inf:issuerName><inf:cusip>517125100</inf:cusip><inf:isin>US5171251003</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>Approval, on an Advisory Basis, of the Compensation of our Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>35030.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>35030.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Larimar Therapeutics, Inc.</inf:issuerName><inf:cusip>517125100</inf:cusip><inf:isin>US5171251003</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>Approval, on an Advisory Basis, of the Preferred Frequency of Future Advisory Votes on the Compensation of our Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>35030.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>35030.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Passage Bio, Inc.</inf:issuerName><inf:cusip>702712209</inf:cusip><inf:isin>US7027122099</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers as disclosed in the proxy statement for the 2026 Annual Meeting.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Passage Bio, Inc.</inf:issuerName><inf:cusip>702712209</inf:cusip><inf:isin>US7027122099</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the frequency of holding future advisory votes on named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>2000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Travere Therapeutics, Inc.</inf:issuerName><inf:cusip>89422G107</inf:cusip><inf:isin>US89422G1076</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2473.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2473.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Travere Therapeutics, Inc.</inf:issuerName><inf:cusip>89422G107</inf:cusip><inf:isin>US89422G1076</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>To indicate, on an advisory basis, the preferred frequency of stockholder advisory votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2473.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>2473.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Viking Therapeutics, Inc.</inf:issuerName><inf:cusip>92686J106</inf:cusip><inf:isin>US92686J1060</inf:isin><inf:meetingDate>05/19/2026</inf:meetingDate><inf:voteDescription>TO APPROVE, ON AN ADVISORY BASIS, THE COMPENSATION OF THE COMPANY'S NAMED EXECUTIVE OFFICERS.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>43890.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>43890.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Alkermes plc</inf:issuerName><inf:cusip>G01767105</inf:cusip><inf:isin>IE00B56GVS15</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>To approve, in a non-binding, advisory vote, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>6540.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>6540.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Geron Corporation</inf:issuerName><inf:cusip>374163103</inf:cusip><inf:isin>US3741631036</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our Named Executive Officers, as disclosed in our Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>150000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>150000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inovio Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>45773H409</inf:cusip><inf:isin>US45773H4092</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the resolution regarding compensation of our named executive officers described in the accompanying proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1286407.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1286407.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Integer Holdings Corporation</inf:issuerName><inf:cusip>45826H109</inf:cusip><inf:isin>US45826H1095</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>To approve, in an advisory non-binding vote, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>8424.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>8424.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Rocket Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>77313F106</inf:cusip><inf:isin>US77313F1066</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>A non-binding, advisory vote on the compensation of our named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>29835.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>29835.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Thermo Fisher Scientific Inc.</inf:issuerName><inf:cusip>883556102</inf:cusip><inf:isin>US8835561023</inf:isin><inf:meetingDate>05/20/2026</inf:meetingDate><inf:voteDescription>An advisory vote to approve named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>100.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>100.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Corcept Therapeutics Incorporated</inf:issuerName><inf:cusip>218352102</inf:cusip><inf:isin>US2183521028</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the company's named executive officers as disclosed in the accompanying proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>8000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>8000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Dianthus Therapeutics, Inc.</inf:issuerName><inf:cusip>252828108</inf:cusip><inf:isin>US2528281080</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation paid to our named executive officers; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>42890.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>42890.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Karyopharm Therapeutics Inc.</inf:issuerName><inf:cusip>48576U205</inf:cusip><inf:isin>US48576U2050</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers, as described in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>70836.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>70836.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Kenvue Inc.</inf:issuerName><inf:cusip>49177J102</inf:cusip><inf:isin>US49177J1025</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>Approve, on a non-binding advisory basis, the compensation of Kenvue Inc.'s named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2449.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2449.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Nuvation Bio Inc.</inf:issuerName><inf:cusip>67080N101</inf:cusip><inf:isin>US67080N1019</inf:isin><inf:meetingDate>05/21/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's Named Executive Officers as disclosed in the Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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YEAR</inf:howVoted><inf:sharesVoted>8100.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Perspective Therapeutics, Inc.</inf:issuerName><inf:cusip>46489V302</inf:cusip><inf:isin>US46489V3024</inf:isin><inf:meetingDate>05/27/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the frequency of advisory stockholder votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>514860.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE 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Therapeutics, Inc.</inf:issuerName><inf:cusip>29664W105</inf:cusip><inf:isin>US29664W1053</inf:isin><inf:meetingDate>05/28/2026</inf:meetingDate><inf:voteDescription>To approve the non-binding advisory resolution on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>19299.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>19299.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Neuronetics, Inc.</inf:issuerName><inf:cusip>64131A105</inf:cusip><inf:isin>US64131A1051</inf:isin><inf:meetingDate>05/28/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding, advisory basis, of the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2088.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2088.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Teva Pharmaceutical Industries Limited</inf:issuerName><inf:cusip>881624209</inf:cusip><inf:isin>US8816242098</inf:isin><inf:meetingDate>05/28/2026</inf:meetingDate><inf:voteDescription>TO APPROVE, ON A NON-BINDING ADVISORY BASIS, THE COMPENSATION FOR TEVA'S NAMED EXECUTIVE OFFICERS</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>5995.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>5995.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Coherus Oncology, Inc.</inf:issuerName><inf:cusip>19249H103</inf:cusip><inf:isin>US19249H1032</inf:isin><inf:meetingDate>05/29/2026</inf:meetingDate><inf:voteDescription>To vote on a non-binding, advisory basis to approve the compensation of the Company's named executive officers (a "Say-on-Pay" vote).</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2524607.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>2524607.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>UnitedHealth Group Incorporated</inf:issuerName><inf:cusip>91324P102</inf:cusip><inf:isin>US91324P1021</inf:isin><inf:meetingDate>06/01/2026</inf:meetingDate><inf:voteDescription>Advisory approval of the Company's executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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YEAR</inf:howVoted><inf:sharesVoted>600.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Xenon Pharmaceuticals Inc.</inf:issuerName><inf:cusip>98420N105</inf:cusip><inf:isin>CA98420N1050</inf:isin><inf:meetingDate>06/02/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Corporation's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>186374.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>186374.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Xenon Pharmaceuticals Inc.</inf:issuerName><inf:cusip>98420N105</inf:cusip><inf:isin>CA98420N1050</inf:isin><inf:meetingDate>06/02/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the frequency of future shareholder advisory votes to approve the compensation of the Corporation's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>186374.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>186374.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Beam Therapeutics Inc.</inf:issuerName><inf:cusip>07373V105</inf:cusip><inf:isin>US07373V1052</inf:isin><inf:meetingDate>06/03/2026</inf:meetingDate><inf:voteDescription>Approve, on an advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>393142.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>393142.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>DBV Technologies SA</inf:issuerName><inf:cusip>23306J309</inf:cusip><inf:isin>US23306J3095</inf:isin><inf:meetingDate>06/03/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Michel de Rosen, Chairman of the Board</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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YEAR</inf:howVoted><inf:sharesVoted>4900.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Aclaris Therapeutics, Inc.</inf:issuerName><inf:cusip>00461U105</inf:cusip><inf:isin>US00461U1051</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement accompanying the proxy card.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>438.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>438.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Amylyx Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>03237H101</inf:cusip><inf:isin>US03237H1014</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>234499.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>234499.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Assembly Biosciences, Inc.</inf:issuerName><inf:cusip>045396207</inf:cusip><inf:isin>US0453962070</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding advisory basis, of our named executive officers' compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>6704.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>6704.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Capricor Therapeutics, Inc.</inf:issuerName><inf:cusip>14070B309</inf:cusip><inf:isin>US14070B3096</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>APPROVAL OF NAMED EXECUTIVE OFFICER COMPENSATION, ON A NON-BINDING ADVISORY BASIS</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>21097.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>21097.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Capricor Therapeutics, Inc.</inf:issuerName><inf:cusip>14070B309</inf:cusip><inf:isin>US14070B3096</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>APPROVAL OF FREQUENCY OF FUTURE NON-BINDING ADVISORY VOTES ON NAMED EXECUTIVE OFFICER COMPENSATION, ONA NON-BINDING ADVISORY BASIS</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>21097.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>21097.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>CG Oncology, Inc.</inf:issuerName><inf:cusip>156944100</inf:cusip><inf:isin>US1569441009</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>64147.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>64147.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>CG Oncology, Inc.</inf:issuerName><inf:cusip>156944100</inf:cusip><inf:isin>US1569441009</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To indicate, on an advisory basis, the preferred frequency of stockholder advisory votes on the compensation of the Company's Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>64147.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>64147.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Edgewise Therapeutics, Inc.</inf:issuerName><inf:cusip>28036F105</inf:cusip><inf:isin>US28036F1057</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>Conduct an advisory vote on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>60398.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>60398.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Gossamer Bio, Inc.</inf:issuerName><inf:cusip>38341P102</inf:cusip><inf:isin>US38341P1021</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation of the Company's named executive officers as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>92931.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>92931.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Ionis Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>462222100</inf:cusip><inf:isin>US4622221004</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To make an advisory vote on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>18358.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>18358.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Kura Oncology, Inc.</inf:issuerName><inf:cusip>50127T109</inf:cusip><inf:isin>US50127T1097</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation of our named executive officers ("Say-on-Pay"), as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>40000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>40000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Kura Oncology, Inc.</inf:issuerName><inf:cusip>50127T109</inf:cusip><inf:isin>US50127T1097</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>Indication, on an advisory basis, of the preferred frequency of holding future Say-on-Pay votes on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>40000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>40000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>MoonLake Immunotherapeutics</inf:issuerName><inf:cusip>61559X104</inf:cusip><inf:isin>KY61559X1045</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>Approval of, on a non-binding, advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>276224.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>276224.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Nektar Therapeutics</inf:issuerName><inf:cusip>640268306</inf:cusip><inf:isin>US6402683063</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve a non-binding advisory resolution regarding our executive compensation (a "say-on-pay" vote).</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>43015.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>43015.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>OrthoPediatrics Corp.</inf:issuerName><inf:cusip>68752L100</inf:cusip><inf:isin>US68752L1008</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our executive officers who are named in the compensation disclosures in this proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>483.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>483.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>PMV Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>69353Y103</inf:cusip><inf:isin>US69353Y1038</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding advisory basis, of the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>74222.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>74222.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Savara Inc.</inf:issuerName><inf:cusip>805111101</inf:cusip><inf:isin>US8051111016</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executives.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>19030.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>19030.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>SI-BONE, Inc.</inf:issuerName><inf:cusip>825704109</inf:cusip><inf:isin>US8257041090</inf:isin><inf:meetingDate>06/04/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve executive compensation "Say-on-Pay".</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>240460.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>240460.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Enliven Therapeutics, Inc.</inf:issuerName><inf:cusip>29337E102</inf:cusip><inf:isin>US29337E1029</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>To approve, in an advisory (non-binding) vote, the frequency of future stockholder advisory votes on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>240460.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>240460.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Intellia Therapeutics, Inc.</inf:issuerName><inf:cusip>45826J105</inf:cusip><inf:isin>US45826J1051</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding advisory basis, of the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>15837.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>15837.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Organon &amp; Co.</inf:issuerName><inf:cusip>68622V106</inf:cusip><inf:isin>US68622V1061</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>Approve, on a non-binding advisory basis, the compensation of Organon's Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3279.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>3279.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Prelude Therapeutics Incorporated</inf:issuerName><inf:cusip>74065P101</inf:cusip><inf:isin>US74065P1012</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve the 2025 compensation for the company's named executive officers (say-on-pay).</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>152825.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>152825.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Prelude Therapeutics Incorporated</inf:issuerName><inf:cusip>74065P101</inf:cusip><inf:isin>US74065P1012</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>Advisory vote on the frequency of advisory votes on named executive officer compensation (say-on-frequency).</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>152825.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>152825.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Voyager Therapeutics, Inc.</inf:issuerName><inf:cusip>92915B106</inf:cusip><inf:isin>US92915B1061</inf:isin><inf:meetingDate>06/09/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>35000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>35000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Clover Health Investments, Corp.</inf:issuerName><inf:cusip>18914F103</inf:cusip><inf:isin>US18914F1030</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Non-binding advisory proposal to approve the compensation paid to our named executive officers for 2025.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>28276.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>28276.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Iovance Biotherapeutics, Inc.</inf:issuerName><inf:cusip>462260100</inf:cusip><inf:isin>US4622601007</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>To approve, by non-binding advisory vote, the compensation of our named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>18187.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>18187.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Iovance Biotherapeutics, Inc.</inf:issuerName><inf:cusip>462260100</inf:cusip><inf:isin>US4622601007</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>To approve, by non-binding advisory vote, the frequency of our future votes on the compensation of our named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>18187.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>18187.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Kiora Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>49721T507</inf:cusip><inf:isin>US49721T5074</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>167941.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>167941.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Lineage Cell Therapeutics, Inc.</inf:issuerName><inf:cusip>53566P109</inf:cusip><inf:isin>US53566P1093</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation paid to our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3317.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>3317.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Milestone Pharmaceuticals Inc.</inf:issuerName><inf:cusip>59935V107</inf:cusip><inf:isin>CA59935V1076</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Say-on-Pay - A non-binding advisory vote on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3549089.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>3549089.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Palisade Bio, Inc.</inf:issuerName><inf:cusip>696389402</inf:cusip><inf:isin>US6963894026</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1933037.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>1933037.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Praxis Precision Medicines, Inc.</inf:issuerName><inf:cusip>74006W207</inf:cusip><inf:isin>US74006W2070</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory (non-binding) basis, the compensation of the named executive officers as disclosed in the Company's proxy statement for the 2026 Annual Meeting of Stockholders pursuant to the applicable compensation disclosure rules of the SEC, including the compensation tables and narrative discussion.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>55.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>55.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Solid Biosciences Inc.</inf:issuerName><inf:cusip>83422E204</inf:cusip><inf:isin>US83422E2046</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>The approval of an advisory vote on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>61.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>61.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Summit Therapeutics Inc.</inf:issuerName><inf:cusip>86627T108</inf:cusip><inf:isin>US86627T1088</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Approval, by a non-binding advisory vote, of the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>88900.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>88900.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>uniQure N.V.</inf:issuerName><inf:cusip>N90064101</inf:cusip><inf:isin>NL0010696654</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation of the named executive officers of the Company.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>82120.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>82120.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>uniQure N.V.</inf:issuerName><inf:cusip>N90064101</inf:cusip><inf:isin>NL0010696654</inf:isin><inf:meetingDate>06/10/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the frequency of advisory votes on the compensation of the named  executive officers of the Company.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>82120.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>82120.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>BeOne Medicines Ltd.</inf:issuerName><inf:cusip>07725L102</inf:cusip><inf:isin>US07725L1026</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>THAT, on a non-binding, advisory basis, the compensation of the Company's named executive officers, as disclosed in the Proxy Statement, for the fiscal year ended December 31, 2025 be and is hereby approved.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>7633.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>7633.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>BioCryst Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>09058V103</inf:cusip><inf:isin>US09058V1035</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To hold a non-binding, advisory vote regarding executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>105000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>105000.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Corvus Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>221015100</inf:cusip><inf:isin>US2210151005</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>32336.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>32336.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Evolus, Inc.</inf:issuerName><inf:cusip>30052C107</inf:cusip><inf:isin>US30052C1071</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>Approval of, on an advisory basis, the compensation of Evolus' named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>55859.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>55859.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Janux Therapeutics, Inc.</inf:issuerName><inf:cusip>47103J105</inf:cusip><inf:isin>US47103J1051</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>174014.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>174014.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Natera, Inc.</inf:issuerName><inf:cusip>632307104</inf:cusip><inf:isin>US6323071042</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory (non-binding) basis, the compensation of Natera, Inc.'s named executive officers as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>519.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>519.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Natera, Inc.</inf:issuerName><inf:cusip>632307104</inf:cusip><inf:isin>US6323071042</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory (non-binding) basis, the frequency of future advisory votes on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>519.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>519.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Pliant Therapeutics, Inc.</inf:issuerName><inf:cusip>729139105</inf:cusip><inf:isin>US7291391057</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To approve, by non-binding advisory vote, the resolution approving Named Executive Officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2584468.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>2584468.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Quince Therapeutics, Inc.</inf:issuerName><inf:cusip>22053A305</inf:cusip><inf:isin>US22053A3059</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>10.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>10.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Whitehawk Therapeutics, Inc.</inf:issuerName><inf:cusip>00032Q104</inf:cusip><inf:isin>US00032Q1040</inf:isin><inf:meetingDate>06/11/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the named executive officers identified in the 2025 Summary Compensation Table in the "Executive Compensation" section of the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>105548.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>105548.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Kyntra Bio, Inc.</inf:issuerName><inf:cusip>31572Q881</inf:cusip><inf:isin>US31572Q8814</inf:isin><inf:meetingDate>06/12/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>10469.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>10469.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Protara Therapeutics, Inc.</inf:issuerName><inf:cusip>74365U107</inf:cusip><inf:isin>US74365U1079</inf:isin><inf:meetingDate>06/12/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation of our named executive officers, as disclosed in the proxy statement</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>457544.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>457544.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Protara Therapeutics, Inc.</inf:issuerName><inf:cusip>74365U107</inf:cusip><inf:isin>US74365U1079</inf:isin><inf:meetingDate>06/12/2026</inf:meetingDate><inf:voteDescription>Vote, on an advisory basis, as to whether the stockholder advisory vote to approve the compensation of our named executive officers, (i.e., Proposal 3) should occur every one, two or three years</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>457544.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>457544.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Regeneron Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>75886F107</inf:cusip><inf:isin>US75886F1075</inf:isin><inf:meetingDate>06/12/2026</inf:meetingDate><inf:voteDescription>Proposal to approve, on an advisory basis, compensation of the Named Executive Officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3413.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>3413.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>WW International, Inc.</inf:issuerName><inf:cusip>98262P200</inf:cusip><inf:isin>US98262P2002</inf:isin><inf:meetingDate>06/12/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the Company's named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>31946.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>31946.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Mirum Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>604749101</inf:cusip><inf:isin>US6047491013</inf:isin><inf:meetingDate>06/15/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1200.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1200.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Vaxcyte, Inc.</inf:issuerName><inf:cusip>92243G108</inf:cusip><inf:isin>US92243G1085</inf:isin><inf:meetingDate>06/15/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding, advisory basis, of the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>47160.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>47160.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Ardelyx, Inc.</inf:issuerName><inf:cusip>039697107</inf:cusip><inf:isin>US0396971071</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of our named executive officers as disclosed in the proxy statement accompanying this notice pursuant to the compensation disclosure rules of the Securities and Exchange Commission ("Say-on-Pay");</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>23900.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>23900.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Ardelyx, Inc.</inf:issuerName><inf:cusip>039697107</inf:cusip><inf:isin>US0396971071</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, whether a Say-on-Pay vote should occur every one (1) year, every two (2) years or every three (3) years;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>23900.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>23900.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Cullinan Therapeutics, Inc.</inf:issuerName><inf:cusip>230031106</inf:cusip><inf:isin>US2300311063</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>Proposal to vote, on an advisory basis, to approve our named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>18321.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>18321.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>IDEAYA Biosciences, Inc.</inf:issuerName><inf:cusip>45166A102</inf:cusip><inf:isin>US45166A1025</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement accompanying this Notice of Annual Meeting of Stockholders; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>16183.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>16183.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Nuvalent, Inc.</inf:issuerName><inf:cusip>670703107</inf:cusip><inf:isin>US6707031075</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation paid to our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4181.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>4181.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>RxSight, Inc.</inf:issuerName><inf:cusip>78349D107</inf:cusip><inf:isin>US78349D1072</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the named executive officers identified in the 2025 Summary Compensation Table in the "Executive Compensation" section of the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>43250.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>43250.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Silence Therapeutics plc</inf:issuerName><inf:cusip>82686Q101</inf:cusip><inf:isin>US82686Q1013</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1099651.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1099651.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Xencor, Inc.</inf:issuerName><inf:cusip>98401F105</inf:cusip><inf:isin>US98401F1057</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory (non-binding) basis, of the compensation of the Company's named executive officers, as disclosed in this Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>40000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>40000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Zentalis Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>98943L107</inf:cusip><inf:isin>US98943L1070</inf:isin><inf:meetingDate>06/16/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory (non-binding) basis, of the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>125745.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>125745.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>4D Molecular Therapeutics, Inc.</inf:issuerName><inf:cusip>35104E100</inf:cusip><inf:isin>US35104E1001</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory, non-binding basis, of the compensation of the Company's named executive officers ("say-on-pay vote").</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>18509.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>18509.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Alector, Inc.</inf:issuerName><inf:cusip>014442107</inf:cusip><inf:isin>US0144421072</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Advisory vote on executive compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>778810.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>778810.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Bicycle Therapeutics Plc</inf:issuerName><inf:cusip>088786108</inf:cusip><inf:isin>US0887861088</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To approve, on advisory basis, the compensation of our named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>29689.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>29689.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>CytomX Therapeutics, Inc.</inf:issuerName><inf:cusip>23284F105</inf:cusip><inf:isin>US23284F1057</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To approve, on a nonbinding advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement accompanying this Notice of Annual Meeting of Stockholders; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2630102.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2630102.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>CytomX Therapeutics, Inc.</inf:issuerName><inf:cusip>23284F105</inf:cusip><inf:isin>US23284F1057</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To hold a non-binding advisory vote on the frequency of future advisory votes by stockholders on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2630102.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>2630102.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Damora Therapeutics, Inc.</inf:issuerName><inf:cusip>G2646Y104</inf:cusip><inf:isin>KYG2646Y1044</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>278111.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>278111.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Damora Therapeutics, Inc.</inf:issuerName><inf:cusip>G2646Y104</inf:cusip><inf:isin>KYG2646Y1044</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To conduct an advisory vote to determine the frequency of future advisory votes on the compensation of the Company's named executive officers;</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>278111.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>278111.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Forward Air Corporation</inf:issuerName><inf:cusip>34986A104</inf:cusip><inf:isin>US34986A1043</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the named executive officers (the "say on pay vote").</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>42078.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>42078.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>GitLab Inc.</inf:issuerName><inf:cusip>37637K108</inf:cusip><inf:isin>US37637K1088</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Approve, on a non-binding advisory basis, the compensation paid by GitLab Inc. to its named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>7200.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>7200.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Guardant Health, Inc.</inf:issuerName><inf:cusip>40131M109</inf:cusip><inf:isin>US40131M1099</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Non-binding advisory vote to approve Guardant Health, Inc.'s named executive officer compensation.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>10000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>10000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Guardant Health, Inc.</inf:issuerName><inf:cusip>40131M109</inf:cusip><inf:isin>US40131M1099</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Non-binding advisory vote on the frequency of stockholder advisory votes regarding compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>10000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>10000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Madrigal Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>558868105</inf:cusip><inf:isin>US5588681057</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve executive compensation</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>289.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>289.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Protagonist Therapeutics, Inc.</inf:issuerName><inf:cusip>74366E102</inf:cusip><inf:isin>US74366E1029</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>908483.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>908483.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Recursion Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>75629V104</inf:cusip><inf:isin>US75629V1044</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Advisory vote to approve executive compensation as disclosed in the 2026 Proxy Statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>4967.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>4967.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>The Oncology Institute, Inc.</inf:issuerName><inf:cusip>68236X100</inf:cusip><inf:isin>US68236X1000</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding, advisory basis, of the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>12706.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>12706.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>The Oncology Institute, Inc.</inf:issuerName><inf:cusip>68236X100</inf:cusip><inf:isin>US68236X1000</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>Approval, on a non-binding, advisory basis, of the preferred frequency of future advisory votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>12706.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>12706.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Zai Lab Limited</inf:issuerName><inf:cusip>98887Q104</inf:cusip><inf:isin>US98887Q1040</inf:isin><inf:meetingDate>06/17/2026</inf:meetingDate><inf:voteDescription>THAT, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement, is hereby approved.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>120891.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>120891.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Agios Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>00847X104</inf:cusip><inf:isin>US00847X1046</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To vote, on an advisory basis, to approve the compensation paid to our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>3536.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>3536.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Allogene Therapeutics, Inc.</inf:issuerName><inf:cusip>019770106</inf:cusip><inf:isin>US0197701065</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>11247.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>11247.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Allogene Therapeutics, Inc.</inf:issuerName><inf:cusip>019770106</inf:cusip><inf:isin>US0197701065</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the preferred frequency of stockholder advisory votes on the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>11247.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>11247.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Crinetics Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>22663K107</inf:cusip><inf:isin>US22663K1079</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers as disclosed in the proxy statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission; and</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>938253.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>938253.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Disc Medicine, Inc.</inf:issuerName><inf:cusip>254604101</inf:cusip><inf:isin>US2546041011</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation paid to the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>384.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>384.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>EyePoint, Inc.</inf:issuerName><inf:cusip>30233G209</inf:cusip><inf:isin>US30233G2093</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation paid to the Company's named executive officers as disclosed in the accompanying proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2000.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>2000.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>NextCure, Inc.</inf:issuerName><inf:cusip>65343E207</inf:cusip><inf:isin>US65343E2072</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>Approval, on an advisory basis, of the compensation paid by Company to its named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>1750.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>1750.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Revolution Medicines, Inc.</inf:issuerName><inf:cusip>76155X100</inf:cusip><inf:isin>US76155X1000</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding, advisory basis, the compensation of the Company's named executive officers as disclosed in the Proxy Statement pursuant to the compensation disclosure rules of the Securities and Exchange Commission ("Say-on-Pay").</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>66934.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>66934.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Supernus Pharmaceuticals, Inc.</inf:issuerName><inf:cusip>868459108</inf:cusip><inf:isin>US8684591089</inf:isin><inf:meetingDate>06/18/2026</inf:meetingDate><inf:voteDescription>To approve, on a non-binding basis, the compensation paid to our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>9847.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>9847.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>BridgeBio Pharma, Inc.</inf:issuerName><inf:cusip>10806X102</inf:cusip><inf:isin>US10806X1028</inf:isin><inf:meetingDate>06/22/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of the Company's named executive officers, as disclosed in the proxy statement.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>118862.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>118862.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>BridgeBio Pharma, Inc.</inf:issuerName><inf:cusip>10806X102</inf:cusip><inf:isin>US10806X1028</inf:isin><inf:meetingDate>06/22/2026</inf:meetingDate><inf:voteDescription>To conduct a non-binding advisory vote on the frequency of future non-binding advisory votes to approve the compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>118862.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>118862.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>LeonaBio, Inc.</inf:issuerName><inf:cusip>04746L203</inf:cusip><inf:isin>US04746L2034</inf:isin><inf:meetingDate>06/22/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>72143.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>FOR</inf:howVoted><inf:sharesVoted>72143.000000</inf:sharesVoted><inf:managementRecommendation>FOR</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>LeonaBio, Inc.</inf:issuerName><inf:cusip>04746L203</inf:cusip><inf:isin>US04746L2034</inf:isin><inf:meetingDate>06/22/2026</inf:meetingDate><inf:voteDescription>To approve, on an advisory basis, the frequency of future stockholder advisory votes on the compensation of our named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>72143.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>ONE YEAR</inf:howVoted><inf:sharesVoted>72143.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Monopar Therapeutics Inc.</inf:issuerName><inf:cusip>61023L207</inf:cusip><inf:isin>US61023L2079</inf:isin><inf:meetingDate>06/22/2026</inf:meetingDate><inf:voteDescription>To approve the compensation of our named executive officers on an advisory, non-binding basis.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>120714.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>120714.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Schrodinger, 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>5696203.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>5696203.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inhibikase Therapeutics, Inc.</inf:issuerName><inf:cusip>45719W205</inf:cusip><inf:isin>US45719W2052</inf:isin><inf:meetingDate>06/26/2026</inf:meetingDate><inf:voteDescription>to vote, on a non-binding, advisory basis, on the frequency of future non-binding, advisory votes on compensation of the Company's named executive officers.</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY 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VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2880021.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>2880021.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inventiva SA</inf:issuerName><inf:cusip>46124U107</inf:cusip><inf:isin>US46124U1079</inf:isin><inf:meetingDate>06/30/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Frederic Cren, CEO until September 30, 2025</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2880021.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>2880021.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inventiva SA</inf:issuerName><inf:cusip>46124U107</inf:cusip><inf:isin>US46124U1079</inf:isin><inf:meetingDate>06/30/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Andrew Obenshain, CEO from October 1, 2025</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2880021.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>2880021.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable><inf:proxyTable><inf:issuerName>Inventiva SA</inf:issuerName><inf:cusip>46124U107</inf:cusip><inf:isin>US46124U1079</inf:isin><inf:meetingDate>06/30/2026</inf:meetingDate><inf:voteDescription>Approve Compensation of Pierre Broqua, Vice-CEO until June 30, 2025</inf:voteDescription><inf:voteCategories><inf:voteCategory><inf:categoryType>SECTION 14A SAY-ON-PAY VOTES</inf:categoryType></inf:voteCategory></inf:voteCategories><inf:sharesVoted>2880021.000000</inf:sharesVoted><inf:sharesOnLoan>0</inf:sharesOnLoan><inf:vote><inf:voteRecord><inf:howVoted>AGAINST</inf:howVoted><inf:sharesVoted>2880021.000000</inf:sharesVoted><inf:managementRecommendation>AGAINST</inf:managementRecommendation></inf:voteRecord></inf:vote></inf:proxyTable></inf:proxyVoteTable>