Filed Pursuant to Rule 424(b)(7)

Registration No. 333-290248

PROSPECTUS SUPPLEMENT NO. 1

(To Prospectus dated September 12, 2025)

KINDLY MD, INC.

357,158,501 Shares of Common Stock

133,100,773 Shares of Common Stock Underlying Pre-Funded Warrants

100,000,000 Shares of Common Stock Issuable Upon Conversion of Convertible Notes

This prospectus supplement supplements the prospectus dated September 12, 2025, relating to the offer and resale by the selling stockholders identified in this prospectus supplement (each, a “Selling Stockholder,” and collectively, the “Selling Stockholders”) of up to an aggregate of 9,356,767 shares of Kindly MD, Inc. (the “Company”) common stock, par value $0.001 per share (“Common Stock”).

This prospectus supplement is being filed solely to update the list of Selling Stockholders to reflect the distribution of shares of Common Stock (the “PIPE Shares”) previously issued to Nakamoto Feeder, a series of Allocations 2025 Master, LLC (“Nakamoto Feeder”), and Columbus Circle Digital I (“Columbus Digital”), to their underlying equityholders. No additional securities are being registered by this prospectus supplement. The shares covered hereby were previously registered for resale pursuant to the registration statement referenced herein.

You should read this prospectus supplement, together with the related prospectus and the additional information described under the headings “Incorporation of Certain Information by Reference” and “Where You Can Find More Information” carefully before you invest in any of our securities.

Our Common Stock is listed with, and trades on, Nasdaq under the ticker symbol “NAKA.” Our tradeable warrants to purchase Common Stock are listed with, and quoted on, the OTC Pink marketplace under the ticker symbol “NAKAW.”

This investment involves a high degree of risk. See “Risk Factors” on page 2 of the prospectus and any similar section contained in the documents that are incorporated by reference therein.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus supplement or the accompanying prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus supplement is September 26, 2025.

The following information is provided to update the Selling Stockholders table in the prospectus to reflect the distribution of shares of Common Stock previously issued to Nakamoto Feeder and Columbus Digital to their respective underlying investors.

SELLING STOCKHOLDERS

The following information is provided as of September 25, 2025 to update the “Selling Shareholders” section of the Prospectus to reflect the pro rata distribution by Nakamoto Feeder to its equityholders of 8,555,115 shares of Common Stock and the pro rata distribution by Columbus Digital to its equityholders of 1,318,750 shares of Common Stock, as reflected in the table set forth below.

With respect to only the Selling Shareholders listed in the table below, the information set forth in the table below supersedes and replaces the information regarding such Selling Shareholders in the Prospectus. Information regarding each of the Selling Shareholders listed in the table below is based on information provided by each of them as of the date of this prospectus supplement.

Information about the Selling Shareholders, including those listed below, may change over time. Since the date of the Prospectus, certain of the Selling Shareholders listed below have sold a portion of their shares of Common Stock registered thereunder and certain other Selling Shareholders may also have sold or otherwise transferred their shares of Common Stock registered thereunder. This prospectus supplement does not provide any updates with respect to any Selling Shareholders not listed in the table below.

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