SCAN TO VIEW MATERIALS & VOTEOCULIS HOLDING AGBAHNHOFSTRASSE 206300 ZUGSWITZERLANDVOTE BY INTERNET - www.proxyvote.com or scan the QR Barcode aboveUse the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 p.m. Eastern Time on May 11, 2026. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.ELECTRONIC DELIVERY OF FUTURE PROXY MATERIALSIf you would like to reduce the costs incurred by our company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years.VOTE BY PHONE - 1-800-690-6903Use any touch-tone telephone to transmit your voting instructions up until 11:59 p.m. Eastern Time on May 11, 2026. Have your proxy card in hand when you call and then follow the instructions.VOTE BY MAILMark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.V95666-P49298OCULIS HOLDING AGTHE BOARD OF DIRECTORS OF THE COMPANY RECOMMENDS THAT YOU VOTE YOUR SHARESFORAGENDA ITEMS 1-12For AgainstAbstain!1.APPROVAL OF THE 2025 ANNUAL REPORT INCLUDING THE 2025 ANNUAL (STATUTORY) FINANCIAL STATEMENTS AND THE 2025 CONSOLIDATED FINANCIAL STATEMENTS!!!For AgainstAbstain2.ALLOCATION OF BALANCE SHEET RESULTS 20253.DISCHARGE TO THE MEMBERS OF THE BOARD OF DIRECTORS AND THE EXECUTIVE COMMITTEE6.RE-ELECTION OF PRICEWATERHOUSECOOPERS SA (LAUSANNE) AS STATUTORY AUDITORS4.ELECTION OF THE CHAIRPERSON AND THE OTHER MEMBERS OF THE BOARD OF DIRECTORS!!!7.ELECTION OF BLUM & PARTNER AG (ZUG) AS INDEPENDENT PROXY4.1Re-election of Anthony Rosenberg as Member and Chairperson of the Board of Directors8.COMPENSATION FOR THE NON-EXECUTIVE MEMBERS OF THE BOARD OF DIRECTORS4.2Re-election of Christina Ackermann8.1Vote on Total Fixed (Non-Performance-Related) Compensation for Non-Executive Members of the Board of Directors until the end of the Company's 2027 Annual General Meeting!!!!!4.3Re-election of Lionel Carnot8.2Vote on Equity or Equity Based Compensation for Non-Executive Members of the Board of Directors until the end of the Company's 2027 Annual General Meeting!!!4.4Re-election of Arshad M. Khanani9.COMPENSATION FOR THE MEMBERS OF THE EXECUTIVE COMMITTEE!!!4.5Re-election of Martijn Kleijwegt9.1Vote on Fixed (Non-Performance-Related) Compensation for Members of the Executive Committee payable in 20279.2Vote on variable Compensation for Members of the Executive Committee payable in 20279.3Vote on Equity Based Compensation for Members of the Executive Committee for 2027!!!4.6Re-election of Geraldine O'Keeffe!4.7Re-election of Riad Sherif!10.NON-BINDING ADVISORY VOTE ON THE 2025 COMPENSATION REPORT4.8Re-election of Robert K. Warner!!4.9 Election of Gregory D. Perry5.ELECTION OF THE MEMBERS OF THE COMPENSATION COMMITTEE!!!11.INCREASE AND AMENDMENT OF CAPITAL BAND*5.1Re-election of Lionel Carnot12.INCREASE OF CONDITIONAL SHARE CAPITAL FOR EMPLOYEE BENEFIT PLANS*!5.2Election of Geraldine O'Keeffe*Please mark either Foror Against because abstentions have the legal effect ofAgainst .5.3Election of Gregory D. PerryNote: Please sign exactly as name appears hereon. When shares are held by joint owners, both should sign. When signing as attorney, executor, administrator, trustee, guardian, or corporate officer, please give title as such.

Important Notice Regarding the Internet Availability of Proxy Materials for the 2026Annual General Meeting of Shareholders:The Meeting Invitation is available at www.proxyvote.comV95667-P49298OCULIS HOLDING AGANNUAL GENERAL MEETING OF SHAREHOLDERSMAY 13, 2026 12:00 PM CEST / 6:00 AM EDTTHIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORSThe undersigned appoints the current independent proxy of the Company, PST Legal AG, as proxy, and authorizes them to represent and to vote, as designated on the reverse hereof, all of the ordinary shares of Oculis Holding AG ( Oculis ), held of record by the undersigned at the close of business on April 15, 2026 at the 2026 Annual General Meeting of Shareholders of Oculis to be held on May 13, 2026, or at any adjournment thereof.THIS PROXY WHEN PROPERLY EXECUTED WILL BE VOTED AS INDICATED. IF NO CONTRARY INDICATION IS MADE, THE PROXY WILL BE VOTED IN FAVOR OF AGENDA ITEMS 1-12, AND IN ACCORDANCE WITH THE JUDGMENT OF THE PROXY NAMED HEREIN ON ANY OTHER MATTERS THAT MAY PROPERLY COME BEFORE THE ANNUAL GENERAL MEETING. THIS PROXY IS SOLICITED ON BEHALF OF THE BOARD OF DIRECTORS.(Continued and to be marked, dated and signed, on the other side)