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Exhibit 107

Calculation of Filing Fee Table

Form S-1

(Form Type)

Septerna, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

 

                 
     Security
Type
  Security
Class Title
  Fee
Calculation
or Carry
Forward
Rule
  Amount
Registered
  Proposed
Maximum
Offering
Price per
Unit
 

Proposed
Maximum

Aggregate

Offering Price(1)(2)

 

Fee

Rate

 

Amount of

Registration

Fee

 
NEWLY REGISTERED SECURITIES
                 

Fees to Be

Paid

  Equity   Common Stock, par value $0.001 per share   457(a)   830,556(1)   $18.00(1)   $14,950,008.00   0.00015310   $2,288.85
                 

Fees Previously

Paid

  —    —    —    —    —    —      — 
 
CARRY FORWARD SECURITIES
                 

Carry Forward

Securities

  —    —    —    —      —       
           
    Total Offering Amounts     $14,950,008.00     $2,288.85
           
    Total Fees Previously Paid         — 
           
    Total Fee Offsets         — 
           
    Net Fee Due               $2,288.85(3)

 

(1)

Represents only the additional number of shares being registered and includes 108,334 shares of common stock that the underwriters have the option to purchase. Does not include the securities that the Registrant previously registered on the Registration Statement on Form S-1 (File No. 333-282469), as amended (the “Prior Registration Statement”).

(2)

Estimated solely for the purpose of computing the registration fee in accordance with Rule 457(a) under the Securities Act of 1933, as amended (the “Securities Act”).

(3)

The registration fee is calculated in accordance with Rule 457(a) under the Securities Act based on the proposed maximum aggregate offering price. The registrant previously registered securities on the Prior Registration Statement having a proposed maximum aggregate offering price of $316,249,992.00, which was declared effective by the Securities and Exchange Commission on October 24, 2024. In accordance with Rule 462(b) under the Securities Act, an additional amount of securities having a proposed maximum aggregate offering price of $14,950,008.00 is hereby registered, which includes shares issuable upon the exercise of the underwriters’ option to purchase additional shares.